tag:blogger.com,1999:blog-2741672436160438708.post13988160421064524..comments2024-03-26T12:50:32.070-07:00Comments on Learning from and about cancer (chronic lymphocytic leukemia or CLL) by Dr. Brian Koffman: A rough day: Bloody nose times two and a tender rash minutes before my CLL and MDS lectures in ChicagoBrian Koffmanhttp://www.blogger.com/profile/13250684684103918493noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-2741672436160438708.post-6956151964104355152012-11-19T12:40:10.241-08:002012-11-19T12:40:10.241-08:00The two RESONATE trials only exclude those with wa...The two RESONATE trials only exclude those with warfarin, but older trials have broader exclusion definitions and include any blood thinners. I believe that the latest understanding is that the issue is only with warfarin and not heparin or Lovenox or any other similar product. Also see the comment re ASH abstract that ibrutinib does not effect platelet function. I will try to review that soon in a new post.Brian Koffmanhttps://www.blogger.com/profile/13250684684103918493noreply@blogger.comtag:blogger.com,1999:blog-2741672436160438708.post-80684470394336931382012-11-19T06:51:34.959-08:002012-11-19T06:51:34.959-08:00There is also an abstract at ASH this year that sh...There is also an abstract at ASH this year that shows ibrutinib does not inhibit platelet function in those taking it. Probably the best study to look at in this case.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-2741672436160438708.post-1804323508674073722012-11-18T07:55:55.332-08:002012-11-18T07:55:55.332-08:00Could you clarify your comments about exclusion wh...Could you clarify your comments about exclusion when taking anticoagulants?<br />I understand warfarin but what about drugs such as heparin? Perhaps there is a reference to these bleeding issues.<br />Be well, TomDAnonymousnoreply@blogger.com