tag:blogger.com,1999:blog-2741672436160438708.post1735333642079406198..comments2024-03-26T12:50:32.070-07:00Comments on Learning from and about cancer (chronic lymphocytic leukemia or CLL) by Dr. Brian Koffman: My Chronic Lymphocytic Leukemia (CLL): More Good NewsBrian Koffmanhttp://www.blogger.com/profile/13250684684103918493noreply@blogger.comBlogger10125tag:blogger.com,1999:blog-2741672436160438708.post-50794667445417320842014-05-02T10:09:43.737-07:002014-05-02T10:09:43.737-07:00Brian, great news here! Funny story, went for my 7...Brian, great news here! Funny story, went for my 7 yr onc visit.. he casually asks if he ever told me I have a 13q deletion ( he did not) and tells me it that is a marker that can mean no treatment.. etc. Thanks Doc, 7 years late! Good work Brian, you are always an inspiration! DebbieDebbie Youngnoreply@blogger.comtag:blogger.com,1999:blog-2741672436160438708.post-83142674795918175752014-04-22T17:12:23.378-07:002014-04-22T17:12:23.378-07:00Great news Doc. You are an inspiration and an educ...Great news Doc. You are an inspiration and an educator. A rare combination these days.Jeffrey Zuckermanhttps://www.blogger.com/profile/17235540247201415923noreply@blogger.comtag:blogger.com,1999:blog-2741672436160438708.post-62071071028552452112014-04-22T02:06:37.287-07:002014-04-22T02:06:37.287-07:00Great news! Really pleased for you. Great news! Really pleased for you. Anonymoushttps://www.blogger.com/profile/09741213984188058004noreply@blogger.comtag:blogger.com,1999:blog-2741672436160438708.post-77695903828365738242014-04-21T19:14:59.758-07:002014-04-21T19:14:59.758-07:00CD4/CD8 ratio is the ratio of two type of T cells ...CD4/CD8 ratio is the ratio of two type of T cells and is a rough marker of one aspect of immunity, famously impaired with HIV+ patients, but also can be messed up in other disease such as CLL that effect the immunity. A normal CBC gives no information on it. You need to do an expensive flow cytometry to get that info. My results were part of my trial.Brian Koffmanhttps://www.blogger.com/profile/13250684684103918493noreply@blogger.comtag:blogger.com,1999:blog-2741672436160438708.post-32817400974585823762014-04-21T12:39:38.725-07:002014-04-21T12:39:38.725-07:00Wow, this is such exciting news to hear. I am so g...Wow, this is such exciting news to hear. I am so glad to hear your good news and how well Ibrutinib is working for you, I pray it will continue to do so. Thank you for your encouragement.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-2741672436160438708.post-19963618163250725842014-04-21T07:27:47.202-07:002014-04-21T07:27:47.202-07:00Hi Brian,
Since it has taken me 31 months to achi...Hi Brian,<br /><br />Since it has taken me 31 months to achieve a CR in the blood and nodes, coupled with your latest report, indicates that we do not know how good Ibru really is nor how long it will take to clear out our cancer to a maximum level. I will be getting a BMB this Monday and although I am not exactly looking forward to the experience I am very curious as to the result which may indicate that I have achieved a CR in the all important marrow. <br /><br />Both our cases as well as others should provide a great deal of optimism for patients who are lucky enough to access Ibru.<br /><br />WWWAnonymoushttps://www.blogger.com/profile/08783029423801860411noreply@blogger.comtag:blogger.com,1999:blog-2741672436160438708.post-13306203097781807922014-04-21T07:20:35.281-07:002014-04-21T07:20:35.281-07:00Great news Brian. Thanks for posting. Great news Brian. Thanks for posting. Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-2741672436160438708.post-61220268907195220702014-04-21T06:34:31.963-07:002014-04-21T06:34:31.963-07:00Loved reading this post Brian! So glad ibu is tam...Loved reading this post Brian! So glad ibu is tamping down... Are you taking an mAb or is this the result without, and if so, now that ibu is approved can you start taking a mAb? I know you know this but for your readers, the mAbs like obinituzumab are able to kill off CLL cells once they are circulating in the blood and out of nodes/marrow.<br /><br />How about your marrow? Your near clean slate on CLL great example of why I hope they get combo pathway inhibitors trialed. So close, how great would it be if adding abt199 or idelalisib or both took you from 28 to 0! No proof that would be the result, but is very plausible.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-2741672436160438708.post-74086050239967416572014-04-21T05:19:56.153-07:002014-04-21T05:19:56.153-07:00Wow. Really great news Brian. For those of us new ...Wow. Really great news Brian. For those of us new to CLL, what is a good way to approximate the "good" T-cell count (CD4/CD8) you mentioned? For example, say that my WBC is 12.3 and my lymphs are 8.9 (72%) and ANC is 2.8. What is the good cell count (CD4/CD8)? Thanks again, and keep on informing us of your progress.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-2741672436160438708.post-59963980470740388212014-04-21T03:26:03.067-07:002014-04-21T03:26:03.067-07:00News just gets better and better.
Thanks for posti...News just gets better and better.<br />Thanks for posting .<br />Michael and Jan DublinAnonymousnoreply@blogger.com