tag:blogger.com,1999:blog-2741672436160438708.post7781808038486336635..comments2024-03-26T12:50:32.070-07:00Comments on Learning from and about cancer (chronic lymphocytic leukemia or CLL) by Dr. Brian Koffman: ASH 2014: Rough Notes from Dr. Clive Zent and Dr. Wiestner on Prognostic Factors and Resistance in CLL (chronic lymphocytic leukemia)Brian Koffmanhttp://www.blogger.com/profile/13250684684103918493noreply@blogger.comBlogger5125tag:blogger.com,1999:blog-2741672436160438708.post-22106015200765149462015-04-04T00:51:08.528-07:002015-04-04T00:51:08.528-07:00To those who asked what I meant when I wrote that ...To those who asked what I meant when I wrote that 13q deletion is the same as no CLL, what I was saying is that those with 13q as their only genetic CLL marker have the same life expectancy as those with no CLL. BrianBrian Koffmanhttps://www.blogger.com/profile/13250684684103918493noreply@blogger.comtag:blogger.com,1999:blog-2741672436160438708.post-76561984469376247752015-04-02T10:54:50.402-07:002015-04-02T10:54:50.402-07:00Hi Brian, I know you meant to only post your quick...Hi Brian, I know you meant to only post your quick notes, but I was astounded when you record under Dr. Zent's transcribed comments about Comparison of Molecular Genetics and Prognosis: "13q the same as no cll". What was your impression with that statement?Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-2741672436160438708.post-38941938432099409792015-03-31T14:46:57.130-07:002015-03-31T14:46:57.130-07:00Great info...what did you mean by "13q same a...Great info...what did you mean by "13q same as no CLL"?AJChttps://www.blogger.com/profile/05674444027324413676noreply@blogger.comtag:blogger.com,1999:blog-2741672436160438708.post-58348975808865420732015-03-31T13:18:09.414-07:002015-03-31T13:18:09.414-07:00I am so sick and tired of hearing the ideology tha...I am so sick and tired of hearing the ideology that if you get rid of most of the CLL what left only grows quicker!!! And I am not slighting the person who made the comment above, I have heard this too much, makes you wonder well what then is the point..we need to have some treatment plan for eradication..trials to start combining therapies with the goal of winning the fight without the high risk and collateral damage from aBMT. I have been on Ibrutinib for almost 2.5 years and have the hope that perhaps a CR will eventually come. I will be 49 in few weeks so I don't see myself taking Ibrutinib for next 30 years...but don't see stopping anytime soon either. CART-T needs to be sped up for CLL patients.. Brian, what is the latest and greatest on CAR-T and what is being done to get those of us stuck on third base home? Perhaps if you could do a post on this for us when you get time, and we all very much appreciate the time you spend on your blog. Sorry but venting...Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-2741672436160438708.post-6027842210458870662015-03-29T07:45:25.082-07:002015-03-29T07:45:25.082-07:00Wow Brian, thanks for posting this. So much good ...Wow Brian, thanks for posting this. So much good information. NOTCH1 and complex karyotype influence on Richters was interesting. This opened my eyes:<br /><br />"No longer believe we develop new clones but start with small one that grow<br />Freq by FISH (which is low) 4-5% year, but in next gen 20% after RX<br />Clinically important for resistance"<br /><br />If I understand this seems to be saying getting rid of only some of the disease makes what's left grow much faster. If true, this confirms the wisdom of not treating until you have to (watch and wait).<br />Anonymousnoreply@blogger.com