Saturday, May 24, 2014

ASH 2013: Dr. John Pagel Speculates on the Future of CLL (chronic lymphocytic leukemia) Therapies including the late breaking data on Idelalisib

In the second part of our interview at ASH 2013 we shift from discussing radio-immune therapy and listen as Dr. John Pagel starts by agreeing with many of us patients that our future could and should see less and less chemotherapy and more and more combinations of targeted therapies.

He then gives his perspective on the late breaking abstract at ASH on idelalisib (AKA CAL 101 AKA GS-1101) plus rituximab versus placebo plus rituximab that Dr. Furman and I also discussed in this prior post that also contains a link to the ASH abstract and the NEJM where it indeed did get published. This trial has been well reviewed in the past, but it was nice to note the agreement among the researchers involved in this large trial.

Here's part two of the three part interview.



More to come soon with the last section of Dr. Pagel's interview and a long three part interview with Dr. Byrd from the same ASH annual conference.

Then all the attention turns to ASCO 2014. ASCO covers all cancers, so CLL is a minor player compared to the big four of breast, colon, lung, and prostate, but there will be important new data on ibrutinib, idelalisib, ABT-199, ONO-4059, a new SYK inhibitor from Gilead and others.

I have several exciting interviews scheduled both in video and simple audio format that I will be posting and sharing with my friend Andrew Schorr on his patient friendly cancer website Patient Power as Andrew made the sensible decision not to fly from Barcelona to Chicago. Andrew's team will also be posting the latest news on several other types of cancer, some of which may have directly relevance to those of us with CLL.

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2 Comments:

Blogger wayne wells said...

More good news on the TKI front. I am glad you pressed on the adverse event observations. Some patients I met who had been on Idelalisib reported interstitial pneumonitis. It seemed to crop up more with Idelalisib than Ibrutinib patients so this was interesting to hear.

Thanks for doing these interviews.

WWW

May 25, 2014 at 5:13 PM  
Anonymous Anonymous said...

As I read about ASH and upcoming ASCO, I am thinking about the progress since you made this video Brian:
http://vimeo.com/album/1723705/video/35208431
In some ways its been amazing, in other ways, slow to get to these combo trials that we really need to see if this thing can be stopped in its tracks. Thanks for all your hard work.

I was worried that when Andrew moved to Barcelona he'd be hard to get back. : )

May 27, 2014 at 10:54 AM  

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