What started as a personal journey of a doctor turned patient morphed into a way to share what’s universal in dealing with cancer, in my case a nasty leukemia (CLL), a failed transplant and a successful clinical trial. The telling of my journey has become a journey to teach about CLL, related blood issues and all cancers. Please visit our new website http://cllsociety.org for the latest news and information. Smart patients get smart care™. If you want to reach me, email bkoffmanMD@gmail.com
Friday, August 28, 2015
ASH 2014: Dr. Jeff Sharman Discusses the Biology of the CLL (chronic lymphocytic leukemia) Cells
In the first of a two-part interview recorded at the 2014 American Society of Hematology annual meeting with Dr. Jeff Sharman, an important CLL researcher and helpful blogger (see http://www.cll-nhl.com), we take a step back and listen as Dr. Sharman explains how our increased understanding of the biology and lifecycle of the CLL cell has resulted in the breakthrough therapies we are enjoying today.
Take Away Points:
Unlike some cancers, CLL is not driven by one particular activating mutation.
B cell receptor signaling is an important driver of CLL proliferation.
The behavior and biology of the CLL cells inside the lymph nodes and the bone marrow is very different than that of the same cells in the blood stream.
CLL cells grow in the nodes and the bone marrow, not the blood stream.
The differences between the biology of the cells in and out of the blood stream have profound implications for therapy.
About 1% of our CLL cells are born and die each day.
Dr. Sharman is a good educator and takes the time to carefully explain what is happening in the lifecycle of our cancer cells.
My more colorful and simplistic analogy comes at the end of the presentation.
A family doc and husband of 1 and father of 4 and grandfather of 3 who loves his family and his work. I live with no TV and no microwave, but wouldn't last a minute without friends, art, music, books and the beach. Hockey, good jokes and exotic travel are pretty important too. Writing, Talmud and Zen give meaning to my life. My diet is organic vegan, often raw. I hope the blog makes the load lighter and the path both safer and more fun for those who read it or are going to similar places. I want to help. I crave your comments. If you are new to the blog, check out the portrait my son Will painted (it is the first post), and my very first text post.