Friday, August 28, 2015

ASH 2014: Dr. Jeff Sharman Discusses the Biology of the CLL (chronic lymphocytic leukemia) Cells

I am posting here the video and comments that can also be found on the CLL Society website.
In the first of a two-part interview recorded at the 2014 American Society of Hematology annual meeting with Dr. Jeff Sharman, an important CLL researcher and helpful blogger (see, we take a step back and listen as Dr. Sharman explains how our increased understanding of the biology and lifecycle of the CLL cell has resulted in the breakthrough therapies we are enjoying today.
Take Away Points:
  • Unlike some cancers, CLL is not driven by one particular activating mutation.
  • B cell receptor signaling is an important driver of CLL proliferation.
  • The behavior and biology of the CLL cells inside the lymph nodes and the bone marrow is very different than that of the same cells in the blood stream.
  • CLL cells grow in the nodes and the bone marrow, not the blood stream.
  • The differences between the biology of the cells in and out of the blood stream have profound implications for therapy.
  • About 1% of our CLL cells are born and die each day.
Dr. Sharman is a good educator and takes the time to carefully explain what is happening in the lifecycle of our cancer cells.
My more colorful and simplistic analogy comes at the end of the presentation.
Here is the video:
Brian Koffman

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Anonymous Anonymous said...

Really really really interesting stuff Brian. Wondering does this new perspective mean a) chemo may be more prescribed than single agent novel therapy until combo novel agents can be as comprehensive against the various factories in our bodies and b) is peripheral blood WBC/ALC--being essentially CLL "exhaust" from our nodal, spleen and marrow CLL factories--as useful as we thought in determining status and extent of our disease?

Looking forward to Part 2 and resolving the cliffhanger!

August 30, 2015 at 11:28 AM  

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