Here are best answers to some questions I recently
received. Please email questions as it is difficult to respond this way.
Remember I am not a hematologist, pathologist, or transplanter.
ANSWER: CD5 is usually only found on T
cells. Its presence on monoclonal B cells is not expected and thus helps diagnose CLL.
Perhaps this chart will help. The information is
gained from flow cytometry. Click on it to see a larger version.
recovery post transplant is slow and complicated and varies from patient to patient and even within each patient themselves. Different immune component may recover at different rates. Suffice it to say, one can remain at increased infection and cancer risk for several years after transplant,
but after about two years, much of the high risk period is behind you, that is assuming
you are no longer on immunosuppressive drugs for graft versus host disease(GVHD) and you are well recovered. For example, routine vaccines are usually begun between 12 and 24 months post allogeneic stem cell transplant, suggesting that your humoral immune system is fairly robust by that time.
Below is some very basic outline of post transplant
3: In looking at the ASCO abstract, information is not
provided as to the cause of treatment interruption. An interruption due to a
drug complication or cll event may have a very different impact on PFS than a
break in care for surgery. Is that data available?
ANSWER: I wish I had that data too. I
do understand that many of the patients were quite sick for multiple
reasons and that's why they quit. Patients who go off drug for a week
or so for a minor surgery as an example should expect better results.
Labels: flow cytometry, ibrutinib, immunity, transplant